Endocrine Abstracts

Background: Individuals with hypoparathyroidism often experience a range of symptoms associated with reduced health-related quality of life (HRQoL) and work productivity. Conventional therapy aims to alleviate hypocalcemia and acute symptoms but fails to restore normal parathyroid hormone (PTH) physiology or improve HRQoL. In the PaTHway trial, 79% of participants treated with TransCon PTH vs. 5% placebo (P<0.0001) met the primary efficacy endpoint (normal serum c...

ObjectiveThe aim of this investigation is to study the redox status of osteoblasts in response to glucose and bacterial lipopolysaccharide (LPS) and their response to minocycline, in a simulated diabetogenic model, using the steroid marker 5 alpha- dihydrotestosterone (DHT)MethodMonolayer cultures of MG63 osteoblasts were established in Eagle’s MEM incubated for 24 h with radiolabelled testosterone, effe...

ObjectiveThis study investigates the oxidative effects of tumour necrosis factor alpha (TNF) and glucose (G) in a cell culture model of osteoblasts and the modifying role of minocycline (M), using a steroid marker of wound healing (5 alpha- dihydrotestosterone: DHT). This model simulates chronic inflammation and hyperglycaemia, relevant to chronic inflammatory periodontal disease in uncontrolled diabetics and prospects of adjunctive management, using min...

Introduction: Both GH and IGF1 have important effects on the heart mass and contractility and deficiency of either hormone is associated with increased cardiovascular morbidity and mortality. GH/IGF1 axis abnormalities (mostly primary or secondary IGF1-D) are frequent in adult patients with β-thalassemia major (β-Thal). IGF1-D could therefore contribute with iron overload to the heart’s damage of β-Thal patients, but this question has been little investigat...

Neuroendocrine molecules play a significant role in the progression of human prostate cancer (PCa) and its neuroendocrine differentiation has been associated to a worse prognosis. Among these molecules, the pleiotropic peptide neuropeptide Y (NPY) was found to be expressed in the human prostate and may show some relevance in PCa progression. In this study, we evaluated the direct effect of NPY on the growth of the human PCa cell lines LNCaP (androgen dependent) and DU145 and P...

Objective: Craving of sweet foods and sucrose may be a big obstacle for glycemic control of diabetic patients. It is generally believed that diabetic patients may prefer sweet taste. However, few studies have examined sucrose preference in diabetic patients. Therefore, we investigated changes in sucrose preference in diabetic condition.Research design and methods: We performed two-alternative staircase methods and forced-choice tracking procedures to ass...

Premature ovarian failure (POF) is characterized by amenorrhea, hypergonadotropism and hypoestrogensm in women under 40 years. Sex steroids play an important role in maintaining bone mass and cessation of ovarian function results in significant bone loss.Objective: To evaluate bone mass density (BMD) and factors influencing it in women with POF.Design & methods: First group of 144 women with spontaneous POF (I), 39.7±7.6 y...

PARADIGHM is an actively recruiting, prospective, observational registry (NCT01922440/EUPAS16927). The primary objective is to evaluate the safety and effectiveness of recombinant human parathyroid hormone, rhPTH(1-84), treatment in patients with chronic hypoparathyroidism under routine clinical care. The secondary objective is tocharacterize the clinical course of chronic hypoparathyroidism under conditions of routine clinical practice. At enrollment, registry inclusion crite...

BackgroundPatients with neuroendocrine neoplasms (NENs) might present with malnutrition due to the tumor itself and/or its treatment. Poor nutritional status and weight loss can lead to poor outcomes, including decreased quality of life, increased complication rates and mortality. Ghrelin is an orexigenic hormone, which is implicated in appetite regulation, body weight, inflammation and immune cell activation. Its gastric secretion mainly depends on the ...

Adrenocortical carcinoma (ACC) is a rare aggressive tumor with a poor prognosis. At present, early diagnosis followed by total surgical tumor resection is the only valuable option for ACC cure and mitotane (MTT) is the only specific drug available for pharmacological treatment. However, its effects seem to be mainly due to its adrenocortical cytotoxicity and its bioavailability and cellular mechanism of action are still unknown, making it difficult to develop less toxic multid...